APOE and anaphylaxis: Indeed, the combination of 5 predictors (hsa-miR-484, hsa-miR-25-3p, hsa-miR-451a, ApoE, and YKL-40) resulted in a random forest model showing good accuracy to differentiate between patients prone to anaphylaxis (i.e., between baseline samples from patients who had anaphylaxis approximately 4 weeks prior to sampling and samples from healthy controls) (Figure 6, A and C).