Familial ALS is linked with the common genetic variants including Cu/Zn superoxide dismutase‐led oxidative stress, and transactive response DNA‐binding protein of 43 kDa (TARDBP), fused in sarcoma and C9orf72 induced RNA processing defect, whereas both genetic and environmental factors have been linked to sporadic ALS. The gene discussed is SOD1; the disease is sarcoma.