Pre-leukemic clones carrying ETV6-RUNX1 oncogenic lesions have been found in 1–5% of healthy newborn cord bloods [20, 21], with differences based mainly on different detection methods, with at an estimated frequency that was 100–500-fold greater than the risk of the corresponding leukemia [7, 20–24]. The gene discussed is RUNX1; the disease is leukemia.