PAX5 and acute lymphoblastic leukemia: The intestinal microbiome of mice genetically predisposed to ALL through Pax5 heterozygosity or ETV6-RUNX1 fusion had a specific shape when compared to wild-type mice, and the alteration of this already distinct microbiome of Pax5 heterozygous mice through antibiotic treatment was able to trigger pB-ALL in the absence of infectious stimuli [71].