Differential gene expression analysis of leukemia-associated non-classical monocytes and their healthy counterpart show a leukemia-associated upregulation of genes involved in monocyte interactions with vascular endothelium during inflammation and vascular endothelial repair, such as PECAM1, CD44, ITGA4, CX3CR1, and TNFSF10, as well as significant downregulation of genes encoding subunits of HLA-DR. Here, ITGA4 is linked to leukemia.