SMAD3 and Familial prostate cancer: In addition, MES TFs, SMAD3, SOX9, WWTR1, and IFI16 had 32, 23, 6, and 5 connections, respectively (Fig. 6C), and KEGG gene enrichment analysis revealed enrichment for ‘breast cancer’, ‘prostate cancer’, and ‘hepatocellular carcinoma’ processes in addition to ‘miRNA in cancer’ terms (Fig. 6D).