SMAD3 and neuroblastoma: Among the MES genes, MEOX1, CBFB and DCAF6 were downregulated, (p = 0.046, 0.0001 and 0.0001, respectively), while SMAD3, ID1, SOX11, ZNF217 and EGR3 were upregulated in NB high-risk groups (p = 0.009, 0.0115, 0.014, 0.021 and 0.035 respectively) (Fig. 1B).