EPHA3 and neuroblastoma: cBioPortal analysis was conducted of 1472 individual NB primary patient tissues previously included in large studies (i.e., Neuroblastoma (AMC Amsterdam), Neuroblastoma (Broad 2013 and 2015), Paediatric Neuroblastoma (TARGET)) using the 485 MES and 369 ADRN associated genes revealing genetic alterations of putative drivers, e.g., EPHA3 A629 splice mutation, FGFR1 N546K missense mutation and LATS2 P479_A480insPP (Additional file 1: Materials S1).