In addition, MES TFs, SMAD3, SOX9, WWTR1, and IFI16 had 32, 23, 6, and 5 connections, respectively (Fig. 6C), and KEGG gene enrichment analysis revealed enrichment for ‘breast cancer’, ‘prostate cancer’, and ‘hepatocellular carcinoma’ processes in addition to ‘miRNA in cancer’ terms (Fig. 6D). The gene discussed is SMAD3; the disease is hepatocellular carcinoma.