ISL1 and adrenal cortex carcinoma: Similarly, OS and DFS for ACC patients expressing SOX11 (HR = 5.2, log-rank test p = 0.00032 and HR = 3.7, log-rank test p = 0.00037) (Fig. 4D, top and bottom) and ISL1 (HR = 6.3, log-rank test p =4.4E−05 and HR = 3.7, log-rank test p = 0.00031) were also reduced (Fig. 4E, top and bottom).