In addition, MES TFs, SMAD3, SOX9, WWTR1, and IFI16 had 32, 23, 6, and 5 connections, respectively (Fig. 6C), and KEGG gene enrichment analysis revealed enrichment for ‘breast cancer’, ‘prostate cancer’, and ‘hepatocellular carcinoma’ processes in addition to ‘miRNA in cancer’ terms (Fig. 6D). This evidence concerns the gene SMAD3 and cancer.