SMAD3 and cancer: Network connectivity followed by KEGG term enrichment of MES TFs revealed that the extended network of genes linked to TFs such as SMAD3, IFI16, and SOX9 was also involved in various cancer regulatory pathways, cancer types, and transcriptional misregulation, while the extended network of GATA2 and GATA3 connected genes has roles in various immune pathways and miRNAs in cancers.