Auranofin and cisplatin, or carboplatin, may interact and act as a ‘vaccine’ in which cancer cells dying by ICD, via DAMPs, activate APCs; these, in turn, present the cancer antigens to T cells in the lymph nodes, leading to the generation of active tumor specific CD8+T cells with the capacity to attacking and killing other cancer cells within the tumor microenvironment [9, 120, 123, 124]. Here, CD8A is linked to neoplasm.