Further experiments proved the direct binding between miR-320a and 3ʹUTR of PD-L1 and overexpression of p53 leads to the upregulation of miR-320a, implying that defective p53-regulated miRNA response led to PD-L1 expression and induced immune evasion in malignant pleural mesothelioma [33]. Here, CD274 is linked to malignant pleural mesothelioma.