SHBG and colorectal carcinoma: For example, the median SHBG concentrations varied substantially between the studies, namely from 42.4 [25] to 221.2 nmol/L (converted from 63.8 ng/ml) [20] in the female controls. This could partially explain the large heterogeneity observed among the studies examining the relationship between SHBG and CRC in post-menopausal women (I2 = 76%).