SHBG and colorectal carcinoma: In the comparisons of the top vs. bottom quartile of sex hormones concentrations, the meta-analyses showed a significant positive association between testosterone and CRC in post-menopausal women but only two studies were included (RR = 1.7, 95% CI: 1.11–2.6; I2 = 0%), while no significant associations were observed for estradiol or SHBG (Additional file 1: Figure S1).