To confirm the involvement of TCF21 in adrenocortical tumor mobility, TCF21 expression was efficiently inhibit in ACAPed-T7 cells by siRNATCF21 as showed in Fig. 2B. Migration and invasion assays using ACAPed-T7siRNATCF21, and respective control cells, showed that inhibition of TCF21 enable the migration and invasion of adrenocortical cells when compared to control cells (Fig. 4). The gene discussed is TCF21; the disease is adrenal cortex neoplasm.