To explore the potential molecular mechanism of TCF21 in cellular mobility of adrenocortical carcinoma cells, we analyzed the effect of TCF21 on the expression of metalloproteinases MMP-2, MMP-8, MMP-9, MMP-14, metalloproteinase inhibitor 1 precursor TIMP-1, KISS-1 and Vimentin (VIM) in H295R/TCF21 cells and respective control. This evidence concerns the gene TCF21 and adrenal cortex carcinoma.