To explore the effect of MMP-8 and MMP-9, both representatives of families of inhibitors and inducers of cell motility [26], in the migration and invasion of adrenocortical tumors, H295R cells were transfected with pCMVMMP-8 and pCMVMMM9 (Figs. 8 and 9). This evidence concerns the gene MMP8 and adrenal cortex neoplasm.