They also showed that over expression of SphK1 markedly inhibited docetaxel or doxorubicin-induced apoptosis via inducing anti-apoptotic proteins such as Bcl-xl, TRAF1, c-IAP1, and c-IAP2 as indicated in Fig. 3, whereas SphK1 inhibition or silencing enhanced NSCLC cells sensitivity to chemotherapy-induced apoptosis [76]. Here, SPHK1 is linked to non-small cell lung carcinoma.