Data suggest possible differential effect of reproductive risk factors and obesity according to breast cancer subtype, with parity, age at menarche, age at first birth, breastfeeding and obesity demonstrating stronger associations with luminal subtype compared to other subtypes [17, 20], however data on the effect of these factors of the intensity of ER and PR staining are scarce. The gene discussed is ESR1; the disease is obesity due to melanocortin 4 receptor deficiency.