2016; Jiang et al. 2015; Wu et al. 2014) but also Ca2+-related signals such as calcineurin and Ca2+/calmodulin-dependent protein kinase II (CaMKII). These also orchestrate cardiac hypertrophy under mechanical overload (van Berlo et al. 2013; Zhou et al. 2010). However, although signaling pathways have been extensively characterized in pressure overload, limited information is available in the case of the involvement in volume overload (You et al. 2018). Here, CAMK2G is linked to cardiac hypertrophy.