The major red flags associated with HCM in RASopathy often include biventricular hypertrophy (PTPN11), plurivalvular abnormalities: majorly pulmonary (PTPN11, SOS1, RAF1, RIT1, SHOC2, NRAS, CBL, BRAF1, MAP2K1, MAP2K2, KRAS, HRAS) but not excluding mitral valve dysplasia (RAF1, PTPN11, SOS1, RIT1, SHOC2, CBL, KRAS). The gene discussed is PTPN11; the disease is RASopathy.