RAF1 and RASopathy: The major red flags associated with HCM in RASopathy often include biventricular hypertrophy (PTPN11), plurivalvular abnormalities: majorly pulmonary (PTPN11, SOS1, RAF1, RIT1, SHOC2, NRAS, CBL, BRAF1, MAP2K1, MAP2K2, KRAS, HRAS) but not excluding mitral valve dysplasia (RAF1, PTPN11, SOS1, RIT1, SHOC2, CBL, KRAS).