miR-375 upregulation appears protective against hypoxia-induced apoptosis of cardiomyocytes via forkhead box P1 (FOXP1) and Bcl like protein 2 (Bcl2l2) upregulation, which may be associated with the observed lower expression of miR-375 in TTTS who had later demise (p = 0.0324). This evidence concerns the gene FOXP1 and twin to twin transfusion syndrome.