IGHE and allergic disease: In conclusion, the present findings demonstrated that DHB attenuated the antiallergic response through the inhibition of the mast cell degranulation, FcεRI expression, the crosslinking of IgE to FcεRI, and allergic cytokine secretion via the NF-κB activation in IgE/BSA-stimulated BMCMCs, and suppressed the allergic reactions in IgE/BSA-stimulation induced PCA model.