PPARGC1A and Parkinson disease: Also, Han et al. [68] reported that fucoidan inhibits MPP+ (1-methyl-4-phenyl-pyridinium, a neurotoxin used to model Parkinson’s disease)-induced generation of ROS, dysfunction of mitochondrial oxidative phosphorylation, and cellular apoptosis in SH-SY5Y cells through regulation of AMPK-PGC-1α.