All nine compounds were tested for cytotoxic activity against three cancer cell lines (colorectal cancer cells (HCT-116), prostate cancer cells (PC-3), and hepatocellular carcinoma cells (SK-Hep-1)) by SRB assay, NO production inhibitory activity in LPS-activated microglial BV-2 cell, and gelatinolysis of extracellular of MMP-9 in human THP-1 monocytic cells S1 protein-simulated. The gene discussed is MMP9; the disease is hepatocellular carcinoma.