Univariate analysis showed that OS was significantly correlated with age >60 years, male, L ≤ 0.5 × 109/L, Plt ≤ 20 × 109/L, APTT > 36 s, PT > 13.5 s, Urea > 8.2 mmol/L, LDH > 1000 U/L, ferritin > 10,000 μg/L, CRP > 100 mg/L were correlated with the overall survival of HLH (p < 0.05). The gene discussed is CRP; the disease is hemophagocytic syndrome.