Within the last 2 years, there have been several very progressive HTA recommendations that have recognized the value of treatments, particularly in rare subpopulations of patients with unique data sets (e.g., crizotinib [8] for ROS1 NSCLC, dabrafenib/trametinib [9] for BRAF-positive NSCLC, larotrectinib [10] as a tumor agnostic treatment [NTRK fusion cancers]). The gene discussed is BRAF; the disease is cancer.