TP53 and cancer: Among these proteins, we mention proteins that are therapeutic targets in several types of cancers: vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR), human epidermal growth factor receptor-2 (Her-2/neu) whose status is involved in the molecular classification of breast cancer, and p53, a well-known predictor both of radiosensitivity and of sensitivity to platinum-based chemotherapy.