At present, probes able to search simultaneously for ALK and ROS-1 rearrangements, such as Vysis ALK/ROS-1 Dual Break Apart Probe Kit (RUO)) or FlexISH ALK/ROS-1 DistinguISH Probe Zytvision, require less tumor material and can be run on cytological samples [67,68]. This evidence concerns the gene ROS1 and neoplasm.