They found that the oxidative stress caused by Cu+ from Cu2O@CaCO3 nanocomposites can efficiently reprogram the macrophages from the M2 phenotype to the M1 phenotype and initiate a vaccine-like immune effect after primary tumor removal, which further induces an immune-favorable tumor microenvironment and intense immune responses for anti-CD47 antibody to simultaneously inhibit distant metastasis and recurrence by immunotherapy [36]. The gene discussed is CD47; the disease is neoplasm.