We speculate that, these individuals are more likely to have an abnormal accumulation of fat (e.g., visceral/ectopic) commonly associated with a significant release of pro-inflammatory cytokines, higher oxidative stress, and reduced anabolic action of insulin-like growth factor-1 (IGF-1) on skeletal muscle, and thus, may lead to sarcopenia [10]. Here, IGF1 is linked to sarcopenia.