In a study of 10 patients with NAFLD and P. gingivalis-associated periodontitis, serum levels of ALT and AST decreased significantly at 1 month following periodontal treatment (oral hygiene instruction, scaling and root planing, and local administration of hydrochloric minocycline), with stable or further decreasing transaminase levels seen at 3 months [69]. This evidence concerns the gene GPT and periodontitis.