SOCS3 and neoplasm: To further identify the downstream target of circSHPRH/miR-942, we first screened 9 tumor suppressors (DLG2, SOCS3, ALX4, GFI1, BARX2, ZNF471, NFKBIA, FOXA2, RRM2B) that were confirmed to be the direct targets of miR-942 in published papers [15, 17–24].