TARDBP and juvenile Huntington disease: 67% (82/122) of them – or their mouse homologs – have already previously been identified in TDP-43 aggregates (Dammer et al., 2012; Zuo et al., 2021), Lewy bodies (McCormack et al., 2019), or α-synuclein-induced aggregates (Mahul-Mellier et al., 2020), or found to aggregate in Huntington’s disease (HD) (Hosp et al., 2017) or Alzheimer’s disease (AD) brains (Hales et al., 2016; Kepchia et al., 2020, Figure 4—figure supplement 2).