Intriguingly, skeletal muscle from C26 tumor‐bearing mice combine typical hallmarks of iron deficiency (i.e., IRP2 upregulation, decrease in both cytosolic and mitochondrial aconitase activity, and mitochondrial iron) with the ones of iron overload (i.e., TFR1 downregulation, increase in ferritin, and in protein‐bound iron). This evidence concerns the gene TFRC and nutritional disorder.