While our system deposits high levels of DNA methylation, we additionally checked whether co‐targeting KRABGFP‐scFv together with the catalytic domain of Dnmt3a and its cofactor Dnmt3L (3a3LGFP‐scFv) would enhance epigenetic inheritance, since such effects have been reported in cancer and primed cell lines (Fig EV2A) (Amabile et al, 2016; Nunez et al, 2021). Here, DNMT3L is linked to cancer.