TNF and acute pancreatitis: Ulinastatin is a serine proteases inhibitor that decreases the inflammation and dysregulated coagulation.7 It has also reversed histological damage and inflammation in the pancreas in the experimental models of severe acute pancreatitis.8 Studies have shown that ulinastatin decreases the C-reactive protein, interleukin-6 and tumor necrosis factor.7 It also decreases the organ dysfunction, the local complication of pancreatitis.