Individual cells are uniform with round to ovoid nucleus, salt and pepper chromatin and scant cytoplasm.3 Immunohistochemistry shows more than 50% tumor cells positive for neuroendocrine tumor markers like chromogranin, synaptophysin and NSE (Neuron-Specific-Enolase).4 Immunohistochemistry is not available in our hospital setting and the diagnosis was based purely on histopathological examination of the excised breast tissue. Here, ENO2 is linked to neuroendocrine neoplasm.