However-it has been found that CRP/Albumin value >5.09 predicts survival among patient with sepsis and septic shock with best sensitivity and specificity.6 Similarly-CRP/Albumin as better prognostic indicator compared to CRP alone in critically ill.23 Several questions remains unanswered at present and future studies on role of CRP to albumin as diagnostic and prognostic marker in sepsis is recommended. The gene discussed is CRP; the disease is Sepsis.