Outcome predicting scoring systems such as Acute Physiology and Chronic Health Evaluation (APACHE) III, Simplified Acute Physiology Score (SAPS) involves multiple variables.9 The early distinction of sepsis status in critically ill patients admitted to ICU is important for timely medical management and improving outcome.8 CRP/Albumin could be a cost-effective two-variable biomarker to stratify patients with sepsis from non-sepsis. The gene discussed is ALB; the disease is Sepsis.