These pyrogens cause the release of cytokines namely, interleukin 1, 2, 6 (IL1, IL2, IL6), Tissue Necrosis Factor (TNF), and Interferon-alpha (INF).14 The cytokines elevate the hypothalamic set point resulting in elevated temperatures.15 In COVID-19, tissue damage or hypoxia causes the release of cytokines thus causing fever.16 A study done by Schneider et al. also suggested that fever is an important feature in severe form of covid-19.17 This evidence concerns the gene TNF and COVID-19.