AIM2 and neoplasm: Notably, large cGAS- and AIM2-recruited cytosolic micronuclei clusters were also observed in the human lung and pancreatic adenocarcinoma cell lines A549 and PANC-1, respectively, after a 24-hour exposure to TTFields at 150 kHz (Supplemental Figure 4, A and C), suggesting that this phenomenon is common in tumor cells and may manifest TTFields’ general effects on the nuclear envelope.