Yet in all 7 GBM lines, there was a 2- to 5-fold AIM2-dependent increase in extracellular release of cytosolic lactate dehydrogenase (LDH) (24, 25) after 24 hours of TTFields treatment, indicating membrane-damaged cell death (Figure 5A and Supplemental Figure 11D). Here, AIM2 is linked to glioblastoma.