In summary, TTFields generate large cytosolic micronuclei clusters via focal nuclear envelope disruption in GBM cells, thereby vigorously recruiting and activating the cGAS/STING and AIM2/caspase 1 inflammasomes to provide danger signals as well as immunogens to generate antitumor immunity against GBM tumors. This evidence concerns the gene CASP1 and glioblastoma.