CASP1 and glioblastoma: Next, to determine if TTFields activate the AIM2-dependent inflammasome in an AIM2-dependent manner, we utilized FAM-YVAD-FMK, a fluorescently labeled, specific, irreversible inhibitor of activated caspase 1, a key AIM2 target, to measure caspase 1 activation in response to TTFields in GBM cells with or without AIM2 depletion.