APP and Alzheimer disease: To demonstrate that these effects extend beyond APP/PS1 mice, we examined the effect of 40 Hz light flicker in 3×Tg mice (Figure S6), another well‐validated AD model, and found significantly reduced soluble Aβ1‐40 and Aβ1‐42 levels, as well as insoluble Aβ1‐40 and Aβ1‐42 levels.