Given CD36 expression is correlated with an immunosuppressive phenotype seen in tumour‐associated macrophages [44], taken with fatty acid uptake being a hallmark feature of alternatively activated macrophages [45], our data suggest that the functions of CD4+Tim4+ tissue‐resident macrophages may be more directed towards tissue remodelling and integrity rather than response to microbial stimulation. The gene discussed is TIMD4; the disease is neoplasm.