As adipose tissue insulin resistance is intricately linked to increased inflammation, the alteration in expression of inflammatory cytokines such as IL6 (Ariemma et al. 2016; Cimmino et al. 2019; Ahmed et al. 2020), IFNG (Ariemma et al. 2016; Miao et al. 2008), TNFA (Miao et al. 2008) that are adipose-derived confirms the effect of BPA exposure leading to chronic inflammation in adipocytes may cause insulin resistance. This evidence concerns the gene TNF and Insulin resistance.