ELP1 and neoplasm: A complete loss of cytoplasmic ELP1 staining in all tumor cells (with intra-tumoral vessels as a positive internal control) was observed in 12/57 (21%) of MB, SHH-activated (Fig. 1a–c), and was preserved in all other MB subgroups (Fig. 1d) and in other tumor types (Supplementary Fig. 1).