Increased astrocytic MAO-B activity due to astrocytosis observed in the brains of patients with Alzheimer’s disease may impart oxidative stress through catalytic reactive oxygen species (ROS) generation.35–37 Therefore, MAO-B inhibition has been proposed as neuroprotective in diseases, where ROS generation is implicated in neurodegeneration and continues to be investigated.38 This evidence concerns the gene MAOB and early-onset autosomal dominant Alzheimer disease.