BDNF and myasthenia gravis: Already da Penha Berzaghi et al.64 showed an increase in hippocampal BDNF levels in rats after treatment with direct parasympathomimetics (pilocarpine) which serve a neuroprotective role during inflammation.65–68 This correlates in humans, with the reported almost four times higher BDNF serum levels in LOMG than in early-onset MG (EOMG).69 In addition, pro-inflammatory cytokines reduce BDNF gene expression.58 Since LOMG is associated with less inflammation than EOMG, this could also be a possible link.