Finally, the growth of large, solid tumor microtissues on RGD-free HAGM cryogels, along with HA-mediated CD44 activation, is probably responsible for the overexpression of genetic markers for hypoxia and tumor aggressiveness, including HIF1α, WNT-11, BCL2, CD73, and VEGF [94,95]. The gene discussed is HIF1A; the disease is neoplasm.