F. nucleatum lipopolysaccharide leads to strong induction of the TLR4/MYD88 innate immune signaling pathway to regulate miRNA expression (Liu et al., 2007), and the expression of specific miRNAs can promote tumor proliferation and the development of chemoresistance through the TLR4/MYD88 pathway (Yang et al., 2017; Yu et al., 2017). This evidence concerns the gene TLR4 and neoplasm.