This result prevailed also after multivariable adjustment for age, sex, BMI, eGFR, Troponin T, BNP, and comorbidities including cancer, asthma, COPD, and heart failure (Adjusted p for association between Lp(a) and PE severity = 0.212, Table 2). The gene discussed is NPPB; the disease is chronic obstructive pulmonary disease.