NT and NTSR1 are then promising candidates for clinical screening for gastrointestinal cancers because of their overexpression in these cancers, and are promising targets because the inhibition of NTSR1 expression or the knockdown of the NTS1 gene decreases oncotic MMP-9 expression and activity (Dong et al., 2017; Sánchez and Coveñas, 2021). The gene discussed is NTSR1; the disease is cancer.