It was found that head and neck cancer samples with high expression of writer genes KIAA1429 were in positive correlation with eraser genes ALKBH3 and FTO, while tumors with a high expression of writer genes (RBM15, RBM15B, and CBLL1) exhibited a low expression of eraser genes (ALKBH3 and FTO). The gene discussed is FTO; the disease is head and neck cancer.