For rs777591A > G located on USP34, after correcting for sex, age, smoking status, and BMI, this site significantly decreased the risk of COPD with the “AA” genotype based on the genotype model (OR: 0.5767, 95%CI: 0.3716–0.8948, p < .05) and recessive model (OR: 0.5942, 95%CI: 0.3927–0.8993, p < 0.05). The gene discussed is USP34; the disease is chronic obstructive pulmonary disease.