A recent study reported widely decreased expression of genes encoding different subunits of GABA-AR, including GABRA1, GABRA2, GABRA3, GABRB3, GABBR1, and GABBR2 (Yang Y. et al., 2021), which is consistent with an earlier study reporting reduced GABRA1, GABRA5, and GABRB2 levels in the cortex of VPA-induced autism models (Chau et al., 2017). Here, GABRB3 is linked to autism.