CGAS and Aicardi-Goutieres syndrome: Notably, genetic depletion of cgas (Gray et al., 2015), sting (Gall et al., 2012), irf3 or ifnar (Stetson et al., 2008) inhibits the IFN-I response and relieves autoinflammatory symptoms, confirming the important contribution of IFN-I to AGS pathology.