In TMEV-IDD, curdlan injection prior to TMEV infection delayed the disease onset and reduced the severity of chronic disease, around 1 month p.i. On the other hand, we previously reported that curdlan injection exacerbated MOG92-106-induced EAE in SJL/J mice, who died around 1 month after EAE induction, where enhancement of CD4+ T-cell and anti-MOG demyelinating antibody responses converted RR-EAE into chronic primary progressive (PP)-EAE (Omura et al., 2019). This evidence concerns the gene CD4 and infection.