Surprisingly in colorectal cancer, lncRNA RP1-85F18.6 is reported to promote proliferation and invasion as well as suppress pyroptosis (112) whereas lncRNA nuclear paraspeckle assembly transcript 1 (NEAT1) could mediate ionizing radiation-induced pyroptosis relying on upregulation of GSDME expression (113). The gene discussed is NEAT1; the disease is colorectal cancer.