Of note, inhibition of the Rev1-CT/RIR interaction was synergistic with the ATM and ATR inhibitor VE-821 and the Wee1 inhibitor MK-1775, leading to the formation of daughter strand gaps (DSGs) in replicating DNA, and sensitising bone osteosarcoma and colon cancer cells to these agents (201). This evidence concerns the gene REV1 and bone osteosarcoma.