WEE1 and colonic neoplasm: Of note, inhibition of the Rev1-CT/RIR interaction was synergistic with the ATM and ATR inhibitor VE-821 and the Wee1 inhibitor MK-1775, leading to the formation of daughter strand gaps (DSGs) in replicating DNA, and sensitising bone osteosarcoma and colon cancer cells to these agents (201).