The tumor stromal-inflammatory interface represents a dynamic space which includes growth factors (hepatocyte growth factor (HGF), insulin-like growth factors (IGF), nerve growth factor (NGF), wingless-type MMTV integration site family member 1 (WNT1), epidermal growth factor (EGF), fibroblast growth factor 2 (FGF2), vascular endothelial growth factor (VEGF), platelet derived growth factor (PDGF)). This evidence concerns the gene HGF and neoplasm.